Binding of isaac best unlocks

Tainted Isaac is a character added in The Binding of Isaac: Repentance. He is the alternate version of Isaac. Tainted Isaac is unlocked by reaching Home and using the Red Key, Cracked Key, or Soul of Cain to access a special room in one of the walls while playing as Isaac. Tainted Isaac can only hold 8 passive items at a time. Tainted Isaac's current …

no way this mf thinks compound fracture and plan c are laz.s best unlocks 💀 Reply reply ... The Binding of Isaac! Members Online. Had a weird dream where there were characters who were the opposite of tainted characters called sanctified characters, tried to draw/describe the ones I remembered from that dream. ...Complete family man, demo man, and waka waka. High brow unlocks a rune that doubles on consumables on the floor. Use it on the chest first room for an extra 4 items, of for great fun combine it with a blank card. Solar system unlocks a rune that copies the d6 effect. Demo man unlocks a card that can instantly kill any enemy, including end …He doesn't have the best unlocks but he unlocks plenty of good stuff - hollow heart is a great trinket, Isaac's Tomb is a good item, and Decap Attack is an underrated active (especially in the early game). ... The Binding of Isaac! Members Online. THE MOTHER OF DEMONS, LILITH!! 2. upvotes ...The Binding of Isaac: Rebirth Items, Trinkets, Tarot Cards and their effects in an easy to use cheat sheet style wiki information page! ... The extra charges appear in yellow on top of the normal green bars. If playing with Afterbirth+, this item works with self-recharging items. Type: Passive. Item Pool: Shop * shop room pool, shop item pool ...© 2024 Google LLC. Disclaimer: This video was made during the Afterbirth+ era, but all of these items are still very powerful and worth unlocking in Repentance. There are some ...The official subreddit for Edmund McMillen's Zelda-inspired roguelite, The Binding of Isaac! ... Good, but do them later: Darkness Falls: Dagaz grants 1 soul heart and cure immunity The Tank: Ansuz gives full mapping ... (and couple of the new booster pack unlocks) and if I could go back and have only algiz and jera unlocked that would really ...

The Lost really went down in the rankings by the Isaac's Heart unlock. If he didn't unlock that, he would have been just above Tainted Bethany in S tier. Additionally, Zodiac and Dad's Lost Coin are fairly meh in terms of item unlocks. While those didn't lose him any points, they also didn't give him many.Magdalene, or Maggy, is a character unlocked by obtaining seven or more heart containers at once in a run. Magdalene is shown as Isaac wearing a yellow wig. Magdalene starts with four red heart containers and the Yum Heart. Magdalene starts with a Speed Up pill after completing the Aprils Fool challenge. She starts with a Full Health pill after completing the Aprils Fool challenge. Both Full ...I'm here to provide a little direction as to the best unlocks to go for first. The goal here is to add killer items into the pool in order to improve the average run and make achieving completion marks easier.The Donation Machine is a type of machine that appears in almost every Shop as well as rarely spawning through Black Markets, Reward Plates, Arcades, and Vaults. Upon touching the Donation Machine, Isaac will donate a coin, causing the displayed coin total to increase by one. Similar to the Greed Donation Machine, the number of coins donated will persist between runs. Donating money will ...Judas. It's really down to which character you're most comfortable with playing as. But as a I learned somewhat recently, if you keep using the same characters, the greed machine will begin to jam a lot more frequently. Isaac is the strongest character in general, with the D6 unlocked.Endings are cutscenes that play at the end of each completed run. They are all different and generally depend on the player's route through the game. There are 16 endings in Rebirth, with 2 more added in Afterbirth, 2 added in Afterbirth+, and another 2 added in Repentance. They can be unlocked by killing the boss at the end of chapters 3-6. They …The Greed Donation Machine appears after every Ultra Greed fight in Greed mode or Greedier mode. Upon touching the Greed Donation Machine, Isaac will donate a coin, causing the displayed coin total to increment. Similar to the Donation Machine, the amount of coins donated will persist between all Greed mode runs. Donating money to the Greed Donation Machine unlocks achievements and items. The ...

Apollyon is a character added in The Binding of Isaac: Afterbirth †. He is unlocked after defeating Mega Satan for the first time. Apollyon starts with two Red Heart containers and Void. Apollyon's strength comes from turning bad items into base stats. This can heavily reduce the need for good luck throughout the run, as runs can be completed while collecting only a few items. Knowing most ...Quick guide where I go over 6 must have items which aren't too difficult to unlock. #bindingofisaac #gaming #gamingguides #repentance Azazel is a character unlocked by making three deals with the Devil in one run. Azazel starts with a short-ranged version of Brimstone which deals damage 13 times in one second 9 times in one second, the ability to fly, 0 - The Fool card, and three Black Hearts without any regular Red Heart containers; however, unlike ??? and Dark Judas / Tainted Judas, Azazel can still obtain Red Heart ... He is the first character with this distinction, and the only one to appear in the original Binding of Isaac - the second being The Lost in Rebirth, third being Keeper in Afterbirth and fourth being The Forgotten in Afterbirth+. The Ankh will resurrect any character as ???, even before he is unlocked.

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Rebirth has a total of 178 unlockable secrets. Afterbirth added 98 new secrets, for a total of 276. Afterbirth † added 63 new secrets, for a total of 339. Booster Pack #5 added 64 new secrets, for a total of 403. Repentance added 237 new secrets, for a total of 640. At the stats screen, pressing Alt + F2 will sync unlocks with Steam achievements. Defeat Satan 5 times to unlock The Negative and Isaac 5 times to unlock The Polaroid. If you get a devil / angel deal from the Mom's Heart fight, you can go into the devil / angel room and progress to Sheol / Cathedral to fight Satan / Isaac. Defeating Mom's Heart 11 times will turn Mom's Heart into It Lives. Defeating It Lives will always ... 8 Apr 2021 ... Comments52 · Luckiest Floor EVER · Ranking Isaac CHALLENGES By Their UNLOCKS · I Simulated The FALLOUT Map At War In WorldBox! · Essentia...Delirious is an unlockable activated item added in The Binding of Isaac: Afterbirth †. Upon use, spawns Delirium in a form of a friendly boss for the current room. Changes the appearance of the current room so it looks like a different chapter. Sometimes bosses don't spawn because of grid entities getting in the way. When this happens, the upper door …Gameplay Gameplay screenshot of The Binding of Isaac, showing Isaac attacking (center) and two enemies (top left and top right). The Binding of Isaac is a top-down dungeon crawler game, presented using two-dimensional sprites, in which the player controls Isaac or other unlockable characters as they explore the dungeons located in Isaac's …Hush is one of only two bosses in the game with a Boss Room scaled in a 2x2 fashion, the other being Delirium. There is an unused file in the game named "boss_hush_skinless" which appears to be an unfinished sprite sheet for the unreleased third form of Hush. It resembles a red, fleshy head.

Tainted Isaac is a character added in The Binding of Isaac: Repentance. He is the alternate version of Isaac. Tainted Isaac is unlocked by reaching Home and using the Red Key, Cracked Key, or Soul of Cain to access a special room in one of the walls while playing as Isaac. Tainted Isaac can only hold 8 passive items at a time. Tainted Isaac's current …Feb 3, 2021 · The Tainted characters, Jacob and Esau, Bethany are missing. Not up to date due to the forgotten and different the lost unlock conditions for the lost. Full guide to all 13 characters in The Binding of Isaac: Rebirth. Includes stats, how to unlock, character-specific unlocks, related achievements, and more. Neither of them are bad, and they're better than almost all of Cain's other unlocks. But they're just kinda lame. Abel is good if you find a Sacrificial Altar. Do T. Lilith next. Sack of sacks is better than Evil Eye and you can’t convince me otherwise.Tainted Keeper is a character added in The Binding of Isaac: Repentance. He is the alternate version of Keeper. Tainted Keeper is unlocked by reaching Home and using the Red Key, Cracked Key, or Soul of Cain to access a special room in one of the walls while playing as Keeper. Tainted Keeper starts with 2 coin hearts and 1 Bomb. Tainted …BoI: Repentance is known to be a bit unstable if you just try to leap into a major mod immediately after unpacking it. Before you play, quit and reload the game once to improve stability. The same ...The Binding of Isaac: Repentance adds all-new, powerful items for players to use, and here is a look at the best ones.The Ascent (the path at the end of which you can unlock Tainted characters) unlocks once you beat the boss of the alt path for the first time. Reply. florosap. • 3 yr. ago. -Red Key (reaching Home) -Echo Chamber (Tainted Apollyon to the Beast) -Rock Bottom (Jacob & Esau to Boss Rush) -Revelation (Bethany to Mother)4 Feb 2023 ... The best mods like Q4 Isaac dance and banger ... Ranking Isaac CHALLENGES By Their UNLOCKS ... The Binding of Isaac in REAL LIFE (Intro Climactic).Unlike Bethany, the other new character added in the Binding of Isaac: Repentance who has a fairly straightforward unlock path, unlocking Jacob & Esau is a bit more complicated. Recommended VideosBut in reality, everyone unlocks their items differently, and there won’t be a “best route to 3,000,000%” path for years to come due to the sheer amount of changes and item introductions. Sounds like Bethany has the best unlocks. Go unlock the Jera rune and dont unlock the others.This is a purely cosmetic bug. Bug! Using Delirious in Mega Satan's fight (after stepping on the pentagram), if Mama Gurdy is spawned, Mama Gurdy will be spawned behind Mega Satan, but it will be able to attack. Bug! If Isaac has Mom's Box and Tick, Mega Satan will start the fight at 70% health, instantly starting the fight at the first wave of ...

From the Sacred Heart to the Magic Mushroom and the mighty Brimstone, here are some of the best and strongest items available in The Binding Of Isaac.

With Lilith there's Serpent's Kiss (Satan), Rune Bag (Isaac), Succubus (the Lamb), Incubus (Hush) and Euthanasia (Delirium) With Keeper there's nothing because fuck Keeper. With Apollyon there's Locust of Conquest (Boss Rush), Smelter (Mom's Heart on hard), Locust of Pestilence (Satan), Locust of Death (the Lamb), Locust of Famine (Blue Baby ... Complete family man, demo man, and waka waka. High brow unlocks a rune that doubles on consumables on the floor. Use it on the chest first room for an extra 4 items, of for great fun combine it with a blank card. Solar system unlocks a rune that copies the d6 effect. Demo man unlocks a card that can instantly kill any enemy, including end bosses.Take down the Heartcoins he spawns. Collect many hearts. I would recommend to take the 8 first runs in a row for most coins. A combination of Habit can be realy usefull. You might want to avoid the 11 round in the shop, if you got problems with the stain and he often spawns in a doublepack there.Ultra Greed is the final boss of Greed Mode and Ending 18. Ultra Greed is fought in a unique vertical double-size room with golden Boss Room doors on all 4 walls in regular positions. When Isaac enters the boss room, Ultra Greed starts out hanging on a noose before he abruptly cuts it off and lands on the ground. Ultra Greed cannot be damaged …© 2024 Google LLC. Disclaimer: This video was made during the Afterbirth+ era, but all of these items are still very powerful and worth unlocking in Repentance. There are some ...The Binding of Isaac: Rebirth. ... So The Lost unlocks are pretty good and Keeper unlocks are a pita. Did anybody ever think about this and did a plan in which order unlocks would be the best ? Last edited by The Unmobable spés; Feb 10, 2018 @ 11:29am < > Showing 1-14 of 14 commentsIsaac's tears turn into large scythes that pierce through enemies (Similar to how Death's scythes look). UNLOCK: Unlock this item by beating Challenge #17 (Waka Waka). Type: Passive, Tear Modifier. Item Pool: Item Room, Devil Room * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, axe, silver, grey, grayGameplay Gameplay screenshot of The Binding of Isaac, showing Isaac attacking (center) and two enemies (top left and top right). The Binding of Isaac is a top-down dungeon crawler game, presented using two-dimensional sprites, in which the player controls Isaac or other unlockable characters as they explore the dungeons located in Isaac's …

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But in reality, everyone unlocks their items differently, and there won’t be a “best route to 3,000,000%” path for years to come due to the sheer amount of changes and item introductions. Sounds like Bethany has the best unlocks. Go unlock the Jera rune and dont unlock the others.The Best Quality 4 Items. The Binding of Isaac: Rebirth / The Best Quality 4 Items. A list of all quality 4 items from The Binding of Isaac: Rebirth, ranked from best to worst. We combined votes from 5 players to create this list. Based on the latest version of The Binding of Isaac: Repentance. Quality is the game's internal tier list for items.Demo Man: Chaos Card = GG. Cursed!: Credit Card is an amazing card for shops. Beans!: Burnt Penny can lead to many bombs. It's in the Cards: SMB is an all-stats up. Slow Roll: Swallow Penny is great for greed and keeper runs. Waka Waka: Death Touch is amazing. The Host: Tech .5 is a straight dps upgrade.The official subreddit for Edmund McMillen's Zelda-inspired roguelite, The Binding of Isaac! ... Best unlocks as tainted . Discussion Hey guys i wanna ask u for your opiniong about the best unlocks as tainted characters Share Sort by: Best. Open comment sort options. Best. Top. New. Controversial. Old. Q&A. Add a Comment.What are some of the most essential / best unlocks in a new save file? Repentance. I played the game for around 30h now and got golden god but I don't know which runs and challenges will unlock cool items. The only thing I know of is donating 874 (?) coins in greed mode for holy mantle with lost. What unlocks would you suggest to get early on ...Shop. Not to be confused with The Shop, a floor in Greed mode. A Shop is a Special Room that sells various pickups and items in exchange for Pennies. Shops require a Key to open, unless Isaac holds Store Key ( except on floor 1, where Shops are always initially unlocked), and appear in every Chapter prior to Womb or including The Womb if Isaac ...Mar 3, 2016 · Unlockables. , , , updated Mar 3, 2016. advertisement. There are many things in The Binding of Isaac: Rebirth that can be unlocked, however, it isn't limited to just items and characters alone ... Mar 28, 2022 · 7 Immaculate Heart. In a frantic, action-laden romp like Isaac, being able to weather offensive barrages and survive is crucial. And while some may view this passive item as being fairly dull in ... 8 May 2021 ... Comments530 ; Unlocking 30 Characters in your VERY FIRST Repentance Run - The Final Barrier. bdLP · 30K views ; The Binding of Isaac Iceberg ... ….

Rebirth has a total of 178 unlockable secrets. Afterbirth added 98 new secrets, for a total of 276. Afterbirth † added 63 new secrets, for a total of 339. Booster Pack #5 added 64 new secrets, for a total of 403. Repentance added 237 new secrets, for a total of 640. At the stats screen, pressing Alt + F2 will sync unlocks with Steam achievements.Killing Beast with him unlocks one of the best items for The Lost Most of the other ones are either niche, not really useful or kinda really bad. In case you know what tainted characters are: tainted forgotten's unlock for beating both Chest and Dark Chest is a decent trinket, his greedier mode unlock sucks, same with the bossrush+hush reward. Therefore, the easiest challenges with the best rewards will be 1/5 or close. (Keep in mind I haven’t played any of the non-repentance challenges in a while so I’m going off of my best memory. Also, I’m using my best guess for Hot Potato, Red Redemption, and DELETE THIS, as those are the only ones I have not currently completed.) Pitch ... The official subreddit for Edmund McMillen's Zelda-inspired roguelite, The Binding of Isaac! ... Good, but do them later: Darkness Falls: Dagaz grants 1 soul heart and cure immunity The Tank: Ansuz gives full mapping ... (and couple of the new booster pack unlocks) and if I could go back and have only algiz and jera unlocked that would really ...The Greed Donation Machine appears after every Ultra Greed fight in Greed mode or Greedier mode. Upon touching the Greed Donation Machine, Isaac will donate a coin, causing the displayed coin total to increment. Similar to the Donation Machine, the amount of coins donated will persist between all Greed mode runs. Donating money to the Greed Donation Machine unlocks achievements and items. The ...Book binding is an important part of the publishing process, and it’s essential to make sure that your books are properly bound before they’re released to the public. There are sev...What is the best way to unlock "Marbles"? Title. Doing a Breaking Run or starting a run with Lazarus, using the pill and if you get Gulp! continue the run saving all your money for pills / Mom's Bottle Of Pills and all your bomba to blow mushrooms. Haven't unlocked it yet, but now that you've got me thinking about it...Bias binding is a versatile technique that adds a professional touch to any sewing project. Whether you’re working on a quilt, garment, or home decor item, bias binding can provide...Off the top of my head: Almost all of Azazel's unlocks are good. Judas' unlocks for Greedier Mode, Boss Rush & Dark Room. Samson Greed Mode. Cain Greedier Mode. Keeper Greedier Mode (The majority of his other unlocks are only to benefit himself) Eden's unlocks for Hush, Isaac & Delirium. Maggy's unlocks for Greed Mode, Satan, …The Lost really went down in the rankings by the Isaac's Heart unlock. If he didn't unlock that, he would have been just above Tainted Bethany in S tier. Additionally, Zodiac and Dad's Lost Coin are fairly meh in terms of item unlocks. While those didn't lose him any points, they also didn't give him many. Binding of isaac best unlocks, The Greed Donation Machine appears after every Ultra Greed fight in Greed mode or Greedier mode. Upon touching the Greed Donation Machine, Isaac will donate a coin, causing the displayed coin total to increment. Similar to the Donation Machine, the amount of coins donated will persist between all Greed mode runs. Donating money to the Greed Donation Machine unlocks achievements and items. The ..., Both normal and Tainted Bethany have good unlocks too (book of virtues and Lemegeton). And stuff like The crane game, fools gold, and Golden trinkets i heard are pretty strong as well, and some of The New reversed arcana cards are pretty good as Well (The stars removes your oldest passive item, and spawns 2 pedestal items from The pool of the ..., Neither of them are bad, and they're better than almost all of Cain's other unlocks. But they're just kinda lame. Abel is good if you find a Sacrificial Altar. Do T. Lilith next. Sack of sacks is better than Evil Eye and you can’t convince me otherwise., Originally posted by Carpel (Daily Workout): Originally posted by Fracastador: I also forgot about abaddon. Abaddon is probably azazel's best unlock other than lilith, in my opinion. The damage + the fear + the huge pile of sin health is an outrageous bargain, and it immediately gives you polaroid/negative synergy., I know i can Alt+F2 but this does not give ne the completion marks back. So i decided to Play every character again to get all completion marks ingame again. Yeah, but then you asked about which order would be best for unlocks. And if you do the Alt-F2 method, you get ALL unlocks AT ONCE. There is no order after that., Jera, Perthro, and Black rune. Rune bag, Blank Card, Blood Penny, Forget Me Now, D6, D20, Cracked Dice, Sack of Sacks, Sack of bombs, Left Hand. All are very good for helping with a game break. 9. , The Binding of Isaac: Epiphany is a mod that aims to add a new variant for all characters in Repentance, called "Tarnished" characters. We have 8/17 characters completed so far, and 1 new character is being added per wave. Each of these characters have a full set of 8 unlocks each, and unlocks can be acquired in other ways too, such as by ..., The Binding Of Isaac's Repentance DLC has added a vast number of new items. Though it's hard to narrow down the best, these ones are stellar. The anticipated final DLC to The Binding Of..., Cain appeared in the original Binding of Isaac and required the same coin count to unlock. Cain is a reference to the Biblical story of Cain and Abel, in which Cain commits the first murder by killing Abel. Abel also appears as an item in Rebirth. Cain's special interaction with Abel is also a reference to this., Both normal and Tainted Bethany have good unlocks too (book of virtues and Lemegeton). And stuff like The crane game, fools gold, and Golden trinkets i heard are pretty strong as well, and some of The New reversed arcana cards are pretty good as Well (The stars removes your oldest passive item, and spawns 2 pedestal items from The pool of the ..., Yesterday I almost had Samson unlocked, but then one rogue bullet came from nowhere on the boss fight against Dingle and messed everything up, yet it still became one of my best runs and I ended up unlocking Ipecac and another piece of the Negative (making it my third). Anyways thanks for the help everyone., It gives different effects depending on which character you're playing and is very strong & fun on some of them. Book of Virtues (Bethany vs Isaac) is good. Most of Tainted Isaac and Tainted Lilith's unlocks are good (but not T Lilith vs Greedier. make sure you don't get that one until you're close to Dead God). 2. , Judas. It's really down to which character you're most comfortable with playing as. But as a I learned somewhat recently, if you keep using the same characters, the greed machine will begin to jam a lot more frequently. Isaac is the strongest character in general, with the D6 unlocked., Keeper is a secret character added in The Binding of Isaac: Afterbirth. Keeper is unlocked by donating 1000 coins to the Greed Donation Machine. Keeper starts with 1 Bomb and a triple shot similar to The Inner Eye. Keeper starts with Wooden Nickel after defeating Isaac with Keeper. Keeper will start with Store Key after defeating Satan with Keeper. Keeper will start with 1 coin pickup after ..., In order to make progression, it is necessary to unlock various characters and chapters. On this page, the unlock requirements for these steps in progression are listed in order of …, Generally Azazel would be the best idea, but any character that's tanky enough or with good abilities to consistency kill the first floor boss in a minute is good also. Cain, Azazel, maybe Maggie (assuming you've unlocked her pill), or even Samson would be a good combination of characters., Ive unlocked him twice now and basically my last and best tip is keep restarting the run until you get either host hat, pyromaniac, or Ludovico Technique. Those items will make it significantly easier. Azazel + A lucky run + Host Hat = Forgotten. :) …, 30 Oct 2021 ... HUGE New Repentance Mod: The Binding of Isaac: Epiphany (Characters, Items, Unlocks, and more!) 55K views · 2 years ago ...more. bdLP. 32K., best unlocks for each character - all of them are listed on the characters page of the wiki. Isaac - mom's knife, d20 (for greed/greedier mode), options?, d infinity, missing poster (needed to unlock the lost), farting baby, isaac's head. Magdalene - candy heart, eucharist, the relic (a cross), celtic cross, purity, censer, maggy's bow, maggy's ..., If you like the video feel free to subscribe and like the video!I ranked all Binding of Isaac Characters by the things they unlock after doing certain ending..., Perthro (Solar system) is better than Dagaz. Unlock that instead. You also forgot some of the best: When life gives you lemons (Card against Humanity) Beans! (Burnt penny) Slow roll (Swallowed Penny) XXXXXXL (Gold heart) Speed! (Get out of jail free card) The Guardian (Blank rune & Clear rune) Pokey mans (Charged key) Cantripped!, Ultra Greed is the final boss of Greed Mode and Ending 18. Ultra Greed is fought in a unique vertical double-size room with golden Boss Room doors on all 4 walls in regular positions. When Isaac enters the boss room, Ultra Greed starts out hanging on a noose before he abruptly cuts it off and lands on the ground. Ultra Greed cannot be damaged …, How To Unlock Bethany in Repentance! - Binding of IsaacAchievements - 403/637 (63%)The Road to Repentance, Getting 1000000% CompletionWatch the 10000000% Vid..., BoI: Repentance is known to be a bit unstable if you just try to leap into a major mod immediately after unpacking it. Before you play, quit and reload the game once to improve stability. The same ..., Judas is a character unlocked after beating Satan for the first time. Judas starts with one red heart container, and has The Book of Belial upon starting, as well as 3 coins. Judas also has a 1.35x damage multiplier. When a character dies after picking up the item Judas' Shadow, they will respawn as Dark Judas. Dark Judas spawns with two Black Hearts, a damage multiplier of 2.00 (instead of ..., 30 Dec 2020 ... Comments418 ; Getting 1000000% (All Achievements) - Binding of Isaac. Priets · 334K views ; Essential Unlockables - The Complete Guide (The Binding ..., Keeper is a secret character added in The Binding of Isaac: Afterbirth. Keeper is unlocked by donating 1000 coins to the Greed Donation Machine. Keeper starts with 1 Bomb and a triple shot similar to The Inner Eye. Keeper starts with Wooden Nickel after defeating Isaac with Keeper. Keeper will start with Store Key after defeating Satan with Keeper. Keeper will start with 1 coin pickup after ..., 30 Oct 2021 ... HUGE New Repentance Mod: The Binding of Isaac: Epiphany (Characters, Items, Unlocks, and more!) 55K views · 2 years ago ...more. bdLP. 32K., But in reality, everyone unlocks their items differently, and there won’t be a “best route to 3,000,000%” path for years to come due to the sheer amount of changes and item introductions. Sounds like Bethany has the best unlocks. Go unlock the Jera rune and dont unlock the others., 1. Unlock the missing poster. This is accomplished by beating the Lamb while playing as Isaac. Since the Lamb is in the Final Boss of the dark room, you will have to unlock it first. You need to unlock the Negative, which you get by beating Satan 5 times., Tainted isaac has one of the best runes and unlocks pretty much the two best items in the game (spindown dice and glitched crown) For other reasons before finding this post, I scored each character's unlock with a number from 1 to 5 with 5 being the best in regards to playing the game's hardest challenges., The Lost really went down in the rankings by the Isaac's Heart unlock. If he didn't unlock that, he would have been just above Tainted Bethany in S tier. Additionally, Zodiac and Dad's Lost Coin are fairly meh in terms of item unlocks. While those didn't lose him any points, they also didn't give him many., The boss rush does not unlock anything if beaten in a challenge. Using Void, Black Rune, Abyss, or Moving Box will start the Boss Rush. If a Chest is opened in the Boss Rush room, it will start the Boss Rush. Mama Mega! will open the Boss Rush room even if the time limit has expired.