Can i take ibuprofen with benadryl

Keppra Interactions. There are 237 drugs known to interact with Keppra (levetiracetam), along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 6 are major, 228 are moderate, and 3 are minor.

Can i take ibuprofen with benadryl. Yes, you can take Benadryl (diphenhydramine) and Dayquil together as they do not interact. However, most people take Dayquil to alleviate cough/cold symptoms without sedation, and taking Benadryl would defeat that purpose (since Benadryl tends to cause drowsiness). ... Concerns Taking Bactrim And Ibuprofen. Can I take ibuprofen …

Taking ibuprofen and Benadryl together is generally safe when directed by a healthcare professional or as indicated on the packaging. However, it's crucial to avoid exceeding the recommended dosage to prevent potential side effects.

Ibuprofen and phenylephrine side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, feeling light-headed, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).. Get …Taking ibuprofen and Benadryl together is generally safe when directed by a healthcare professional or as indicated on the packaging. However, it's crucial to avoid exceeding the recommended dosage to prevent potential side effects.Share Feedback. Adults and children 12 and over may take 25 to 50 milligrams (mg) of Benadryl every four to six hours as needed. Children 6 to 11 may take 12.5 to 25 milligrams every four to six hours as needed. Only give Benadryl to children under 6 years old if their healthcare provider recommends it.Cold compresses and OTC pain relief such as acetaminophen and ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) may also be used if not contraindicated. Swelling associated with a minor injury may be treated at home with a cold compress or ice pack, which can be applied for 15-20 minutes every 2-3 hours.Oct 7, 2021 · Can You Take Benadryl With An Inhaler. 4.8/5Benadryldoes. View interaction reports for Benadryl and the medicines listed below. Advil ; clonazepam. Cymbalta ; Subsequently, question is, can toddler take albuterol and Benadryl? No interactions were found between albuterol and Benadryl Children’s Allergy. This does not necessarily mean no ...

Jul 12, 2018 · Based on the severity of your reaction to ibuprofen, you should discuss the symptoms you are experiencing with your doctor. Benadryl (diphenhydramine) may help reduce the severity of swelling and itching. It typically helps to relieve symptoms of most types of allergic reactions, with the exception certain reactions mediated by T-cells. clonazePAM diphenhydrAMINE. Applies to: clonazepam and Benadryl (diphenhydramine) Using clonazePAM together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Benadryl (diphenhydramine) can safely be taken with Motrin (ibuprofen) and there is no interaction between the two medications. Motrin PM actually contains both of these medications in a single dose (ibuprofen 200 mg & diphenhydramine 38 mg). Benadryl Information. Diphenhydramine is a sedating antihistamine marketed under …Pietra enters the commerce enablement sector with a revamped monthly subscription membership for access to free software tools. The direct-to-consumer business world continues to b...Benadryl is a common medication for allergies, but it can also cause some side effects. Some of them are mild, such as drowsiness, dry mouth, and dizziness, while others are more serious, such as ...Benadryl (diphenhydramine) can safely be taken with Motrin (ibuprofen) and there is no interaction between the two medications. Motrin PM actually contains both of these medications in a single dose (ibuprofen 200 mg & diphenhydramine 38 mg). Benadryl Information. Diphenhydramine is a sedating antihistamine marketed under …

Common options include: Acetaminophen (Tylenol): Reduces pain and fever, but does not reduce inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Motrin) and naproxen (Aleve): Reduce pain, inflammation, and fever. Aspirin: Reduces pain, inflammation, and fever. However, most tattoo artists recommend avoiding OTC ...Diphenhydramine is an antihistamine medicine that relieves the symptoms of allergies. It's known as a drowsy (sedating) antihistamine and is more likely to make you feel sleepy …If medication is past its expiration date, discard it and replace it with new product, says the makers of Benadryl. However, many medications are safe and effective well past their...Children 6 to 11 years: 12.5 to 25 mg, every 4 to 6 hours. Children under 6 years: Use only under the direction of a doctor. For pain and itchy skin from hives, insect bites, and other causes ...Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor commonly prescribed for conditions such as high blood pressure, heart failure, and heart attacks. It works by relaxing the blood vessels, reducing blood pressure, and increasing blood flow tо the heart. Lisinopril is also used to prevent kidney problems in people with diabеtes.Benadryl, a popular antihistamine, contains diphenhydramine. This is commonly used to treat symptoms of allergies or the common cold such as sneezing, itching, watery eyes, and runny nose. Mucinex DM on the other hand is made up of two key components – dextromethorphan and guaifenesin. Dextromethorphan acts as a cough suppressant while ...

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There are certain drugs that should be avoided when taking benzonatate due to their potential interactions. Examples of such drugs include: Alcohol: Mixing alcohol with benzonatate can lead to increased drowsiness and may exacerbate the medication's sedative effects. It is advisable to avoid consuming alcohol while taking benzonatate.Common options include: Acetaminophen (Tylenol): Reduces pain and fever, but does not reduce inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Motrin) and naproxen (Aleve): Reduce pain, inflammation, and fever. Aspirin: Reduces pain, inflammation, and fever. However, most tattoo artists recommend avoiding OTC ... A total of 393 drugs are known to interact with ibuprofen . Ibuprofen is in the drug class Nonsteroidal anti-inflammatory drugs . Ibuprofen is used to treat the following conditions: Aseptic Necrosis. Back Pain. Chronic Myofascial Pain. Chronic Pain. Costochondritis. Diffuse Idiopathic Skeletal Hyperostosis. Diphenhydramine and ibuprofen is a combination medicine used to treat occasional insomnia associated with minor aches and pains. diphenhydramine and ibuprofen is not for use in treating sleeplessness without pain, or sleep problems that occur often.Ibuprofen (Advil, Motrin) Naproxen (Aleve, Naprosyne) ... And you can take antihistamines, including Benadryl. Just talk to your GI doctor anytime you take anything, including OTC drugs. They can ...

Benadryl (diphenhydramine) can safely be taken with Motrin (ibuprofen) and there is no interaction between the two medications. Motrin PM actually contains both of these medications in a single dose (ibuprofen 200 mg & diphenhydramine 38 mg). Benadryl Information. Diphenhydramine is a sedating antihistamine marketed under …Most of the over-the-counter medications used to treat colds and fevers can be used safely while taking an ADHD drug. If you or your child takes an amphetamine (brand names Adderall, Dexedrine, and others), you may want to avoid antihistamines.Amphetamines may counteract the sedative effect of antihistamines, and …Benadryl, a popular antihistamine, contains diphenhydramine. This is commonly used to treat symptoms of allergies or the common cold such as sneezing, itching, watery eyes, and runny nose. Mucinex DM on the other hand is made up of two key components – dextromethorphan and guaifenesin. Dextromethorphan acts as a cough suppressant while ...The answer to whether you can take Benadryl and Ibuprofen at the same time depends on various factors, including your medical history, current health condition, and the dosage of each medication. Potential Risks. Combining Benadryl and Ibuprofen may increase the risk of certain side effects, such as drowsiness, dizziness, and dry mouth. Both ...Yes, you can. Benadryl and Tylenol have not been shown to interact with each other. They’re generally safe to take together, so long as you stick to the dosage as …Benadryl (diphenhydramine) can safely be taken with Motrin (ibuprofen) and there is no interaction between the two medications. Motrin PM actually contains both of these medications in a single dose (ibuprofen 200 mg & diphenhydramine 38 mg). Benadryl Information. Diphenhydramine is a sedating antihistamine marketed under …Benadryl. A total of 446 drugs are known to interact with Benadryl . Benadryl is in the following drug classes: anticholinergic antiemetics, anticholinergic antiparkinson agents, antihistamines, miscellaneous anxiolytics, sedatives and hypnotics . Benadryl is used to treat the following conditions: Allergic Reactions. Allergic Rhinitis. Allergies.Oct 7, 2021 · Can You Take Benadryl With An Inhaler. 4.8/5Benadryldoes. View interaction reports for Benadryl and the medicines listed below. Advil ; clonazepam. Cymbalta ; Subsequently, question is, can toddler take albuterol and Benadryl? No interactions were found between albuterol and Benadryl Children’s Allergy. This does not necessarily mean no ... Can You Take Benadryl With An Inhaler. 4.8/5Benadryldoes. View interaction reports for Benadryl and the medicines listed below. Advil ; clonazepam. Cymbalta ; Subsequently, question is, can toddler take albuterol and Benadryl? No interactions were found between albuterol and Benadryl Children’s Allergy. This does not necessarily mean no ...Common Benadryl side effects may include: dizziness, drowsiness, loss of coordination; dry mouth, nose, or throat; constipation, upset stomach; dry eyes, blurred vision; or. day-time drowsiness or "hangover" feeling after night-time use. This is not a complete list of side effects and others may occur.

Answer. It is safe to combine DayQuil and ibuprofen. There is no known drug interaction between them. It is important to note that there are several 'DayQuil' products available on the market, including: While all these products contain slightly different ingredients, they are all safe to take with ibuprofen.

Is It Safe to Take Benadryl, Zyrtec, Claritin, and Allegra Together? Written by Kevin Le, PharmD, BCPS, BCPPS | Reviewed by Joshua Murdock, PharmD, BCBBS. …143 items in 10 pages. 868. 2-Naphthol. C 10 H 8 O. High. All. 754. Acetanilide (acetanilid) C 8 H 9 N O.Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet. Solution.NSAID Warnings. Prednisone (sold as Rayos, Prednisone Intensol) and Advil (ibuprofen) are among the most common medications for pain and inflammation. Although they are largely safe on their own, taking them together significantly increases the risk of potential side effects, including bleeding in the gastrointestinal (GI) tract.Can you take ibuprofen and Benadryl at the same time? It’s a common question that many people have when they’re dealing with multiple symptoms. Ibuprofen is a nonsteroidal …Tylenol can be taken on its own, but there are many multi-symptom cold & flu remedies that also contain acetaminophen as an active ingredient. These include: Alka-Seltzer Plus Cold & Flu. Contac Cold + Flu. Coricidin HBP Cold & Flu. Equate Cold & Flu Multi-Symptom Relief. Mucines Cold & Flu. Robitussin Multi-Symptom Cough Cold + Flu.Descriptions. Ibuprofen and oxycodone combination is used to relieve acute, moderate to severe pain. Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) that is used to relieve inflammation, swelling, and pain. Oxycodone is a narcotic analgesic that acts in the central nervous system to relieve pain. If oxycodone is used for a long time ...

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Cautions with other medicines. If you take other medicines that lower blood pressure, such as ramipril or lisinopril, at the same time as amlodipine, the combination can sometimes lower your blood pressure too much. When your blood pressure is low, you may feel dizzy or faint. If this keeps happening to you, tell your doctor as your dose may ...Applies to: Mucinex DM (dextromethorphan / guaifenesin) and Benadryl (diphenhydramine) Using dextromethorphan together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor ...Common Benadryl side effects may include: dizziness, drowsiness, loss of coordination; dry mouth, nose, or throat; constipation, upset stomach; dry eyes, blurred vision; or. day-time drowsiness or "hangover" feeling after night-time use. This is not a complete list of side effects and others may occur.Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet. Solution.Flexeril‚ or cyclobenzaprine‚ is primarily used to relieve muscle pain‚ stiffness‚ and discomfort caused by musculoskeletal conditions. It is commonly prescribed for the following purposes: Muscle spasms: Flexeril is often prescribed to treat muscle spasms associated with injuries‚ sprains‚ strains‚ or other musculoskeletal trauma.Benadryl and Tylenol have not been shown to interact with each other. They’re generally safe to take together, but this holds so long as you stick to the dosage as recommended by your doctor or pharmacist. In fact, most doctors recommend Benadryl coupled with pain medications like Tylenol or Ibuprofen to help with sinus symptoms.Keppra Interactions. There are 237 drugs known to interact with Keppra (levetiracetam), along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 6 are major, 228 are moderate, and 3 are minor.Yes, you can safely take acetaminophen and ibuprofen together. And it may surprise you that taking these two medications together actually works better to relieve pain than taking them separately. Studies have shown that ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) together work well to relieve certain types of pain, and with few side ...Benadryl is used to treat the following conditions: Allergic Reactions; Allergic Rhinitis; Allergies; Cold Symptoms; Cough; Eustachian Tube Dysfunction; Extrapyramidal …Is it safe to mix ibuprofen and Benadryl? This article explores the potential risks, benefits, and precautions of taking these two medications together. Yes, you can take diphenhydramine together with painkillers such as paracetamol or ibuprofen. If you take diphenhydramine with painkillers that contain codeine (such as co-codamol) or other prescription painkillers, you may feel very tired and sleepy. Do not drive, ride a bike or operate machinery or tools if this happens to you. ….

Applies to: Vicks NyQuil Severe Cold & Flu (acetaminophen / dextromethorphan / doxylamine / phenylephrine) and Benadryl (diphenhydramine) Using dextromethorphan together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also …Sudafed ( pseudoephedrine) and Benadryl ( diphenhydramine) can be safely taken together as there is no interaction between the two medications. In fact, there are products available over the counter that combine both ingredients to ease administration of both drugs. However, it is important to be aware that Benadryl and Sudafed can have ...KPN News: This is the News-site for the company KPN on Markets Insider Indices Commodities Currencies StocksAdults can take one or two ibuprofen 200mg tablets (200mg to 400mg) three or four times daily if they need to. You should only take ibuprofen every 4 to 6 hours. You should not take more than 6 tablets (1200mg) in total in one day if you have bought them over the counter, from a supermarket or drug store. You should always try and take the ...No interactions were found between Benadryl Allergy Plus Congestion and ibuprofen. However, this does not necessarily mean no interactions exist. Always consult your …Based on the severity of your reaction to ibuprofen, you should discuss the symptoms you are experiencing with your doctor. Benadryl (diphenhydramine) may help reduce the severity of swelling and itching. It typically helps to relieve symptoms of most types of allergic reactions, with the exception certain reactions mediated by T-cells.Additionally, individuals with specific medical conditions or who are taking other medications should exercise caution when considering this combination. Potential Interaction between Benadryl and Ibuprofen. When it comes to managing allergies or pain, you might find yourself wondering if you can take Benadryl and Ibuprofen together.Yes, Benadryl ( diphenhydramine) may be safely taken with Tylenol ( acetaminophen) as there is no drug interaction between the two. In fact, these two drugs can often be found together in the same product. For one example, both of the active ingredients are in the product Tylenol PM, which is used to relieve pain while helping to … Can i take ibuprofen with benadryl, The bottom line. Benadryl can be taken short-term as an OTC sleep aid in adults and kids ages 12 years and older. But it’s typically not a go-to medication for chronic insomnia. Adults ages 65 years and older, people with narrow-angle glaucoma, and kids under 12 should avoid Benadryl for sleep. Dry mouth, dizziness, and constipation are a …, Children 6 to 11 years: 12.5 to 25 mg, every 4 to 6 hours. Children under 6 years: Use only under the direction of a doctor. For pain and itchy skin from hives, insect bites, and other causes ..., Tylenol can be taken on its own, but there are many multi-symptom cold & flu remedies that also contain acetaminophen as an active ingredient. These include: Alka-Seltzer Plus Cold & Flu. Contac Cold + Flu. Coricidin HBP Cold & Flu. Equate Cold & Flu Multi-Symptom Relief. Mucines Cold & Flu. Robitussin Multi-Symptom Cough Cold + Flu., Acetaminophen (Tylenol®, regular or extra strength) is generally regarded as safe to use during IVF to relieve pain or reduce fever. [3,4] There are mixed results from studies when determining whether nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil®, Midol®, and Motrin®), naproxen (Aleve®), and aspirin are safe. [3,4 ..., A doctor has provided 1 answer. Dr. Al Hegab answered. Specializes in Allergy and Immunology. Possible with cautio: Sudafed (pseudoephedrine), Benadryl (diphenhydramine) and Ibuprofen are all otc, labels should be read carefully and care not to exceed recommended doses, they don't interact but use caution with multiple drugs., diphenhydrAMINE food. Applies to: Advil PM (diphenhydramine / ibuprofen) and Benadryl (diphenhydramine) Ask your doctor before using diphenhydrAMINE together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking diphenhydrAMINE. You should be warned not to exceed recommended dosages and to ... , Tylenol. Benadryl Cold/Flu. Alka-Seltzer Plus Cold & Flu. Theraflu Severe Cold & Cough. NyQuil. Coricidin HBP Cold & Flu. Vicks DayQuil Cold & Flu. Tylenol (or generic acetaminophen) can be combined with ibuprofen. You can also take Tylenol while taking naproxen., A total of 393 drugs are known to interact with ibuprofen . Ibuprofen is in the drug class Nonsteroidal anti-inflammatory drugs . Ibuprofen is used to treat the following conditions: Aseptic Necrosis. Back Pain. Chronic Myofascial Pain. Chronic Pain. Costochondritis. Diffuse Idiopathic Skeletal Hyperostosis., Tylenol. Benadryl Cold/Flu. Alka-Seltzer Plus Cold & Flu. Theraflu Severe Cold & Cough. NyQuil. Coricidin HBP Cold & Flu. Vicks DayQuil Cold & Flu. Tylenol (or generic acetaminophen) can be combined with ibuprofen. You can also take Tylenol while taking naproxen., Benadryl, a popular antihistamine, contains diphenhydramine. This is commonly used to treat symptoms of allergies or the common cold such as sneezing, itching, watery eyes, and runny nose. Mucinex DM on the other hand is made up of two key components – dextromethorphan and guaifenesin. Dextromethorphan acts as a cough suppressant …, Montelukast (Singular) is an oral medication used to treat asthma and seasonal allergies. Medications that can interact with montelukast include gemfibrozil …, A total of 393 drugs are known to interact with ibuprofen . Ibuprofen is in the drug class Nonsteroidal anti-inflammatory drugs . Ibuprofen is used to treat the following conditions: Aseptic Necrosis. Back Pain. Chronic Myofascial Pain. Chronic Pain. Costochondritis. Diffuse Idiopathic Skeletal Hyperostosis. , Dec 15, 2021 · Ibuprofen/diphenhydramine can make you sleepy or dizzy during the day, which can affect your ability to focus, think, or react. Taking 1 pill at night instead of 2 pills can help. Don't take ibuprofen/diphenhydramine unless you can get a full night's sleep. Don't drive until you know how the medication affects you. , Hyatt has announced that a new Unbound Collection hotel is coming to the Swiss resort town of Davos in 2023. We may be compensated when you click on product links, such as credit c..., Medicine Matters Sharing successes, challenges and daily happenings in the Department of Medicine ARTICLE: Endomyocardial Biopsy Characterization of Heart Failure With Preserved Ej..., Sep 6, 2021 · In short, no. “People don’t think of over-the-counter medicine as being medicine at all,” says internist Janet Morgan, MD, “but it absolutely is medicine, and like anything else, it’s ... , ALPRAZolam diphenhydrAMINE. Applies to: Xanax (alprazolam) and Benadryl (diphenhydramine) Using ALPRAZolam together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination., See full list on drugs.com , This means they can generally be taken together without resulting in adverse drug-to-drug interactions. 2.2. Cumulative Side Effects Both Benadryl and Ibuprofen have drowsiness as a potential side effect. Even though the sedative effect is more associated with Benadryl, the combined use can intensify this drowsiness, requiring caution. , Specializes in Pediatrics. Yes: There is no interaction between the two medicines. Be sure you know the individual doses of each. Both can be given every 6 hours as needed. Also, some Benadryl (diphenhydramine) preparations have ibuprofen already in it, so make sure you don't double dose with one of these. Read ingredient list carefully on each ..., Meclizine can interact with sleep medications, benzodiazepines, and allergy medications like Benadryl. It can also interact with opioids, dronabinol, and alcohol. Most commonly, these interactions can cause more drowsiness. While some interactions might be mild, others could be potentially dangerous for you., Benadryl, a popular antihistamine, contains diphenhydramine. This is commonly used to treat symptoms of allergies or the common cold such as sneezing, itching, watery eyes, and runny nose. Mucinex DM on the other hand is made up of two key components – dextromethorphan and guaifenesin. Dextromethorphan acts as a cough suppressant …, Feb 14, 2024 · Is it safe to mix ibuprofen and Benadryl? This article explores the potential risks, benefits, and precautions of taking these two medications together. , Key takeaways: Gabapentin (Neurontin) can interact with medications and substances that make you sleepy. These include opioids, benzodiazepines, and alcohol. Gabapentin can interact with some over-the-counter (OTC) medications and supplements. These include antihistamines as well as products that contain magnesium or aluminum., Benadryl. A total of 446 drugs are known to interact with Benadryl . Benadryl is in the following drug classes: anticholinergic antiemetics, anticholinergic antiparkinson agents, antihistamines, miscellaneous anxiolytics, sedatives and hypnotics . Benadryl is used to treat the following conditions: Allergic Reactions. Allergic Rhinitis. Allergies., Acetaminophen (Tylenol®, regular or extra strength) is generally regarded as safe to use during IVF to relieve pain or reduce fever. [3,4] There are mixed results from studies when determining whether nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil®, Midol®, and Motrin®), naproxen (Aleve®), and aspirin are safe. [3,4 ..., Azithromycin is a versatile antibiotic that can effectively combat a range of bacterial infections. It is commonly prescribed for respiratory tract infections such as bronchitis, pneumonia, and sinusitis. Additionally, it can be used to treat certain sexually transmitted infections (STIs) like chlamydia and gonorrhea., First, the answer to whether you can take Ibuprofen and Benadryl together is generally yes. Both medications belong to different drug classes – Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation. At the same time, Benadryl is an antihistamine used to treat allergies., Benadryl (diphenhydramine) Claritin (loratadine) Colace (docusate) Cymbalta (duloxetine) Eliquis (apixaban) Fish Oil (omega-3 polyunsaturated fatty acids) ... Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Unknown: No interaction information available., Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect. 5. Tips. Benadryl may be taken with or without food. Take exactly as directed., Meclizine can interact with sleep medications, benzodiazepines, and allergy medications like Benadryl. It can also interact with opioids, dronabinol, and alcohol. Most commonly, these interactions can cause more drowsiness. While some interactions might be mild, others could be potentially dangerous for you., This means they can generally be taken together without resulting in adverse drug-to-drug interactions. 2.2. Cumulative Side Effects Both Benadryl and Ibuprofen have drowsiness as a potential side effect. Even though the sedative effect is more associated with Benadryl, the combined use can intensify this drowsiness, requiring caution. , Since prednisone does tend to cause insomnia in many individuals, over-the-counter (OTC) medications, like Benadryl, are commonly used to help sleep in the evening. Fortunately, as mentioned above, diphenhydramine is safe to use with prednisone and there are no safety issues taking both together.