Methocarbamol and tizanidine

Feb 11, 2012 · Last updated on 11 February 2012 by Rajive Goel. My Dr recently abruptly stopped my Soma Rx & replaced w/ Zanaflex. Thanks 2 all the info & help I got here, he's willing 2 prscribe it again at next appt if I try Robaxin (those r the only 2 I haven't tried. I searched & can't find anything on taking Zanaflex & Robaxin 750 at the same time.

Methocarbamol and tizanidine. Jan 30, 2017 · Muscle relaxants are used to treat two different conditions: (1) spasticity from upper motor neuron syndromes as occurs in multiple sclerosis and (2) muscular pain or spasms from peripheral musculoskeletal diseases or injury such as low back pain. The muscle relaxants in current use have variable mechanisms of action, efficacy and adverse effects.

Tizanidine is a muscle relaxant that may help minimize muscle spasms. Learn more about tizanidine, including its uses, dosage, and potential side effects and warnings.

Goal of this investigation. In this randomized, 4-arm clinical trial conducted among a population of ED patients with acute, functionally-impairing, non-radicular LBP, we wished to determine whether a daily regimen of ibuprofen plus baclofen, metaxalone, or tizanidine would provide greater relief of LBP than ibuprofen plus placebo one week after an ED …Jan 10, 2019 · The full list of muscle relaxants used in our cohort included baclofen, dantrolene, metaxalone, carisoprodol, chlorzoxazone, cyclobenzaprine, methocarbamol, tizanidine, or orphenadrine. Diagnoses Associated With Muscle Relaxant Use Methocarbamol And Alcohol. Methocarbamol and alcohol act on the nervous system. The former works by blocking nerve impulses (pain sensations) that are being sent to the brain while the latter works by altering the membranes of the brain, which leads to sedation and reduction of pain. Moreover, Robaxin’s primary use is muscle …Tizanidine is a centrally acting alpha-2 agonist with muscle-relaxant, sedative, and anxiolytic properties. It has been used to treat pain associated with muscle spasms, and myofascial and neuropathic pain [34-36]. In 2016, Yazicioğlu et al. studied tizanidine use after inguinal hernia repair in a randomized double-blind study. The primary ...The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. Reply.methocarbamol, chlorzoxazone, baclofen, or dantrolene compared to placebo in patients with musculoskeletal conditions. There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone. Dantrolene, and to a lesser degree ...Oct 23, 2020 · Muscle relaxants used in dystonia include cyclobenzaprine, tizanidine, metaxalone, carisoprodol, methocarbamol, orphenadrine, and chlorzoxazone [34, 35], with evidence for their use derived only from anecdotal use or case reports. Methocarbamol and Aspirin Tablet Description. Methocarbamol tablets USP a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties. The chemical name of methocarbamol is 3- (2-methoxyphenoxy)-1, 2-propanediol 1-carbamate and has the …

There's a constant flow of "email is/is not broken" articles across the internet, but most of them miss the point. Email as a system is not broken, but we, through our email behavi...Store your methocarbamol tablets at room temperature, 68 to 77F (20 to 25C). 6. Response and effectiveness. Methocarbamol starts working in about 30 minutes and its full effects are seen within 2 hours. Methocarbamol is relatively short-acting and needs to be taken three to four times a day as directed by a doctor. 7.The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. Reply.Tizanidine and Methocarbamol are muscle relaxants used to treat muscle pain and spasms. Both the medications work against the exact cause and work in the …Mixing muscle relaxers and alcohol can make the effects of muscle relaxers more intense — and not in a good way. This can lead to potentially dangerous symptoms, such as: increased drowsiness or ... More about Methocarbamol. Ratings & Reviews. Cyclobenzaprine has an average rating of 5.9 out of 10 from a total of 617 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 31% reported a negative effect. Methocarbamol has an average rating of 6.3 out of 10 from a total of 297 ratings on Drugs.com. 51% of reviewers reported ...

Gabapentin is an anticonvulsive medication that is primarily used to treat seizures and nerve pain. It was initially developed as a muscle relaxer and anti-spasmodic medication, but its anticonvulsive properties were discovered later. Gabapentin is also used as an adjunct to more potent anticonvulsants and for the management of certain types of ...Best Answer. It is not so much which is stronger, as much as what the function of the medication is. Methocarbamol is used to treat muslce spams, whereas Zanaflex is used to treat spascity, or ...Applies to: methocarbamol and tizanidine. Using tiZANidine together with methocarbamol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol ...There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone. Dantrolene, and to a lesser degree chlorzoxazone, …Metaxalone has an average rating of 7.2 out of 10 from a total of 127 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 18% reported a negative effect. Methocarbamol has an average rating of 6.3 out of 10 from a total of 297 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 30% reported a negative ...There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone. Dantrolene, and to a lesser degree chlorzoxazone, have been associated with rare serious hepatotoxicity.

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Robaxin (methocarbamol) and Zanaflex (tizanidine hydrochloride) are muscle relaxants used in slightly different ways. Robaxin used together with rest and physical therapy to …Methocarbamol works by depressing the central nervous system, which helps to relax the muscles. Cyclobenzaprine, on the other hand, works by blocking nerve impulses or pain sensations that are sent to the brain. The choice between the two may depend on individual response and tolerability.Oct 23, 2020 · Muscle relaxants used in dystonia include cyclobenzaprine, tizanidine, metaxalone, carisoprodol, methocarbamol, orphenadrine, and chlorzoxazone [34, 35], with evidence for their use derived only from anecdotal use or case reports. I have cervical myelomalacia and narrowing from C6-T2. Tizanidine 4 mgs was short acting and I woke up at 3am, like a light switch. Then I was switched to 750mgs Methacarbamol 4 X’s a day and I’m thinking if this lasts, I can postpone my cervical decompression surgery. It would be posterior due to a 4 level ACDF that was done in 2010.

Apr 4, 2023 · Tizanidine relaxes muscles by dampening down nerve impulses that are sent from spasming muscles along nerve fibers to the brain. Tizanidine belongs to the class of medicines known as central alpha-2-adrenergic agonists. It may also be called a centrally-acting muscle relaxant. 2. Methocarbamol (Robaxin®). Orphenadrine (Norflex®). Antispastic skeletal muscle relaxants that providers can currently prescribe in the U.S. include: Baclofen (Lioresal®). Dantrolene (Dantrium®). Two skeletal muscle relaxants have both antispastic and antispasmodic effects. They include: Tizanidine (Zanaflex®). Diazepam (Valium®).May 19, 2023 ... Methocarbamol is a muscle relaxant medication that works by reducing muscle spasms and pain. It is not known to cause serotonin syndrome, as it ... Robaxin (methocarbamol) and Zanaflex (tizanidine hydrochloride) are muscle relaxants used in slightly different ways. Robaxin used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Acetaminophen and methocarbamol (United States: Not available): Drug information Acetaminophen and pseudoephedrine: Drug information Acetaminophen, caffeine, and pyrilamine: Drug informationHome sales are predicted to be hot in mid-April during the "best week" for real estate in 2023. But high mortgage rates could play spoiler. By clicking "TRY IT", I agree to receive...Methocarbamol works by depressing the central nervous system, which helps to relax the muscles. Cyclobenzaprine, on the other hand, works by blocking nerve impulses or pain sensations that are sent to the brain. The choice between the two may depend on individual response and tolerability.Muscle relaxers are a group of drugs used to treat musculoskeletal pain, meaning pain involving muscles, bones, joints, and connective tissues like ligaments and tendons. Muscle relaxers are sometimes prescribed to people with osteoarthritis ("wear-and-tear" arthritis) as well as those with lower back pain, neck pain, and other …concluded that methocarbamol did not improve pain control in the first 3 dfollowing ays of admission traumatic injury. Tizanidine . Tizanidine is a centrally acting alpha-2 adrenergic agonist. In 1988 there were 2 studies published by , Hutchinson et al. investigating the use of tizanidineplus ibuprofen or aspirin. In the first, patients withApr 4, 2023 · Tizanidine relaxes muscles by dampening down nerve impulses that are sent from spasming muscles along nerve fibers to the brain. Tizanidine belongs to the class of medicines known as central alpha-2-adrenergic agonists. It may also be called a centrally-acting muscle relaxant. 2.

The ultimate decision to transition the patient to methocarbamol and stop taking tizanidine for pain control highlights the importance of individualized care. The …

Diclofenac has an average rating of 7.4 out of 10 from a total of 691 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 20% reported a negative effect. Tizanidine has an average rating of 6.1 out of 10 from a total of 377 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 30% reported a negative effect. More about Methocarbamol. Ratings & Reviews. Cyclobenzaprine has an average rating of 5.9 out of 10 from a total of 617 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 31% reported a negative effect. Methocarbamol has an average rating of 6.3 out of 10 from a total of 297 ratings on Drugs.com. 51% of reviewers reported ... This review included other muscle relaxants such as metaxalone, baclofen, tizanidine, orphenadrine, and chlorzoxazone. In a head-to-head trial between methocarbamol and cyclobenzaprine, there was no significant difference in …Methocarbamol Methocarbamol is a muscle relaxer that works by calming your nervous system. After you start taking it, you’ll usually take 750 mg or 1,000 mg by mouth 3 or 4 times per day. It can be used by people ages 16 and older. Reproductive studies for methocarbamol haven’t been done in animals.The FDA has not approved tizanidine to treat neck or back pain. For multiple sclerosis or cerebral palsy, tizanidine tends to have fewer side effects than Baclofen. But either medication may not make much difference in new low back pain when compared with ibuprofen alone. Tizanidine is not a first choice for new neck or back muscle pain. 6 ...The Geriatric Lexi-Drugs database recommends the avoidance of muscle relaxants other than diazepam and tizanidine in patients older than age 65 years …Bottom Line. Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation. The dosage should be individualized and because it only lasts for a short time in the body, can be taken on an as needed basis. Monitoring of liver enzymes is required. 5.Feb 2, 2024 · Methocarbamol, a muscle relaxant with a distinct mechanism of action from tizanidine, was chosen to ensure adequate pain control while minimizing the risk of adverse events. This approach aligns with the principle of individualized care, recognizing the need to tailor treatment strategies to the unique characteristics and tolerances of each ...

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Your credit score plays an important role in the rates you’ll pay for car insurance and home insurance — and your score can even influence your life insu... Get top content in our ...Methocarbamol (Robaxin) is an oral medication used to treat muscle pain and stiffness. Learn about side effects, warnings, dosage, and more.Indices Commodities Currencies StocksThere is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone. Dantrolene, and to a lesser degree chlorzoxazone, have been associated with rare serious hepatotoxicity.Methocarbamol vs Tizanidine. Muscle relaxants Methocarbamol vs Tizanidine are the go-tos when it comes to muscle spasm and spasticity medications. This does not dispute the efficacy of Robaxin generic versions. Zanaflex is a brand name for Tizanidine and is also a prescription medication; hence care should be taken when …Compare Methocarbamol vs Tizanidine head-to-head with other drugs for uses, ratings, cost, side effects and interactions.Methocarbamol Interactions. There are 342 drugs known to interact with methocarbamol, along with 2 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 28 are major, and 314 are moderate.There are 342 drugs known to interact with methocarbamol, along with 2 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 28 are ... cyclobenzaprine, baclofen, tizanidine, diazepam, Flexeril, Valium, Robaxin, chlorpromazine, Soma, Thorazine. Related Stories.Oct 1, 2022 · People with liver disease should avoid tizanidine, and those with kidney disease should take baclofen in lower doses. Also, avoid the drugs carisoprodol (Soma), chlorzoxazone (generic only), cyclobenzaprine (Amrix), metaxalone (Metaxall), methocarbamol (Robaxin), and orphena-drine (generic only) because of their risk for drowsiness and falls. Prescription Muscle Relaxers. Prescription muscle relaxers are stronger than OTC options but may come with more pronounced side effects. Methocarbamol: A muscle relaxer that is available OTC in other countries but not the United States, methocarbamol treats muscle pain in the back and tends to have fewer sedative effects than other types of muscle relaxers. ….

Home sales are predicted to be hot in mid-April during the "best week" for real estate in 2023. But high mortgage rates could play spoiler. By clicking "TRY IT", I agree to receive...Muscle relaxers are a group of drugs used to treat musculoskeletal pain, meaning pain involving muscles, bones, joints, and connective tissues like ligaments and tendons. Muscle relaxers are sometimes prescribed to people with osteoarthritis ("wear-and-tear" arthritis) as well as those with lower back pain, neck pain, and other …Table of contents. Methocarbamol. Cyclobenzaprine. Carisoprodol. Metaxalone. Tizanidine. Baclofen. Oxazepam and diazepam. Chlorzoxazone. …Cyclobenzaprine should be taken at doses ranging from 5-10 mg three times per day with no more than 30 mg daily, while Tizanidine usually begins with 2-4 mg per day but can increase up to 36 mg as needed. In addition, Cyclobenzaprine remains active longer once ingested due to its much larger half-life (18 hours) than Tizanidine, which in ...Muscle spasms and related pain can be highly debilitating, affecting our daily activities and overall quality of life. Methocarbamol and cyclobenzaprine are commonly prescribed medications for muscle relaxation. While both drugs aim to alleviate muscle discomfort, they differ in various aspects, including their mechanisms of action, uses, side effects, …Methocarbamol is a centrally acting muscle relaxant, which doctors primarily use for treating musculoskeletal pain. Possible side effects may include lightheadedness, drowsiness, and dizziness ...Mar 21, 2024 · After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects. The recommended starting dose of tizanidine is 2 mg every 6 to 8 hours, up to a maximum of 3 doses in 24 hours. Do not take more than 36 mg of tizanidine in a 24-hour period. The brand name of this medication is Robaxin®. What is this medication? METHOCARBAMOL (meth oh KAR ba mole) treats muscle pain and stiffness.Tizanidine Tizanidine is similar in structure to α2 agonists, such as clonidine.5 Tizanidine functions as a centrally acting skeletal muscle relaxant. It decreases presynaptic and postsynaptic excitatory neurotransmitter release, resulting in decreased locus coeruleus activity. 5 Thus, tizanidine can modulate descending motor regulatory pathways.Key takeaways: Tramadol (Ultram, ConZip, Qdolo) is an opioid medication used to treat pain. It has many possible drug interactions, including some antidepressants, antibiotics, and diuretics. Some … Methocarbamol and tizanidine, Methocarbamol (Robaxin®). Orphenadrine (Norflex®). Antispastic skeletal muscle relaxants that providers can currently prescribe in the U.S. include: Baclofen (Lioresal®). Dantrolene (Dantrium®). Two skeletal muscle relaxants have both antispastic and antispasmodic effects. They include: Tizanidine (Zanaflex®). Diazepam (Valium®)., The muscle relaxants that are included in this review are: benzodizepines (diazepam and tetrazepam), non‐benzodiazepines antispasmodics (cyclobenzaprine, carisoprodol, chlorzoxazone, mepobramate, methocarbamol, metaxalone, orphenadrine, tizanidine and flupirtine), and antispasticity drugs (baclofen and dantrolene sodium)., There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone., The full list of muscle relaxants used in our cohort included baclofen, dantrolene, metaxalone, carisoprodol, chlorzoxazone, cyclobenzaprine, methocarbamol, tizanidine, or orphenadrine. Diagnoses Associated With Muscle Relaxant Use, Lower-cost generic is available. Ratings & Reviews. Methocarbamol has an average rating of 6.3 out of 10 from a total of 297 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 30% reported a negative effect. Zanaflex has an average rating of 7.5 out of 10 from a total of 117 ratings on Drugs.com. 67% of reviewers reported ..., The workplace isn’t just the office anymore—so Microsoft Office needs to catch up. The shift to remote work has not been kind to Microsoft—its productivity software is literally na..., 4 days ago · Viloxazine. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adagrasib. Alfentanil. Alprazolam. Amantadine. Benzhydrocodone. , Tizanidine is a centrally acting alpha-2 agonist with muscle-relaxant, sedative, and anxiolytic properties. It has been used to treat pain associated with muscle spasms, and myofascial and neuropathic pain [34-36]. In 2016, Yazicioğlu et al. studied tizanidine use after inguinal hernia repair in a randomized double-blind study. The primary ..., Dosage and Administration. The recommended starting dose of tizanidine is 2 mg. Treatment can be repeated at 6 to 8 h intervals as needed. The dose of tizanidine can be gradually increased by 2–4 mg per dose, with intervals of 1–4 days between each increase, until a satisfactory reduction in muscle tone is achieved., Dr prescribed tizanidine for muscle spasms due to chronic back issues following L5S1 fusion in 2016/2017. My only complaint about this medication is that it makes me drowsy during the day.. Dr switched me to methocarbamol to eliminate drowsiness. First we tried 500mg, it was not effective. Then we tried 750mg, and its still not effective., Meloxicam interacts with blood thinners, some antidepressants, and certain blood pressure medications. Lithium (Lithobid), methotrexate (Trexall), and alcohol also interact with it. Keep an updated list of any medications or supplements you're taking. Have your healthcare provider and pharmacist review your list regularly for potential ..., Diclofenac has an average rating of 7.4 out of 10 from a total of 691 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 20% reported a negative effect. Tizanidine has an average rating of 6.1 out of 10 from a total of 377 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 30% reported a negative effect., Jun 25, 2020 · Lauren Ingeno. C: 215-327-2203. [email protected]. For Patients and the General Public: 1-800-789-7366. For Media Queries & Requests (24/7): 215-662-2560. Post. – Office visits for ongoing prescribing of skeletal muscle relaxant drugs tripled from 2005 to 2016, according to a new study from researchers in the Perelman ... , Home sales are predicted to be hot in mid-April during the "best week" for real estate in 2023. But high mortgage rates could play spoiler. By clicking "TRY IT", I agree to receive..., Tizanidine. Methocarbamol. A cannabis extract containing dronabinol and cannabidiol (trade name Sativex®). Most muscle relaxant preparations are available as tablets, capsules, or liquids. Baclofen is also available as an injection into the back (an intrathecal injection)., Meloxicam interacts with blood thinners, some antidepressants, and certain blood pressure medications. Lithium (Lithobid), methotrexate (Trexall), and alcohol also interact with it. Keep an updated list of any medications or supplements you're taking. Have your healthcare provider and pharmacist review your list regularly for potential ..., There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone., Jun 24, 2019 · Mixing muscle relaxers and alcohol can make the effects of muscle relaxers more intense — and not in a good way. This can lead to potentially dangerous symptoms, such as: increased drowsiness or ... , More about Zanaflex ( tizanidine ) Ratings & Reviews. Robaxin has an average rating of 6.3 out of 10 from a total of 81 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 30% reported a negative effect. Zanaflex has an average rating of 7.5 out of 10 from a total of 117 ratings on Drugs.com. 67% of reviewers reported a ..., Tizanidine. Tizanidine has both antispasmodic and antispastic effects. ... Methocarbamol is an OTC nonbenzodiazepine, antispasmodic medication. A common brand name for it in the U.S. is Robaxin., Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. Tizanidine effectively works with spasticity caused by multiple sclerosis‚ an acquired brain injury‚ or a spinal cord injury. It has also been shown to be clinically effective in managing patients suffering from chronic neck and ..., Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. Tizanidine effectively works with spasticity caused by multiple sclerosis, an acquired brain injury, or a spinal cord injury. It has also been shown to be clinically effective in managing patients suffering from chronic neck and lumbosacral neuralgia with a myofascial component to ..., Using tiZANidine together with methocarbamol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol during treatment., May 13, 2022 ... For the four most used SMRs, we included 35 940, 12 167, 7981 and 6054 users of cyclobenzaprine, tizanidine, baclofen and methocarbamol, and ..., We compare the side effects and drug effectiveness of Methocarbamol and Tizanidine hydrochloride from 78,193 people who take the 2 drugs. The phase IV clinical study is created by eHealthMe based on reports of people who take Methocarbamol and/or Tizanidine hydrochloride, and is updated regularly., If you have a car that does not have a built-in system, you will need acell phone car mount. Here are the top cell phone car mounts. If you buy something through our links, we may ..., There's a constant flow of "email is/is not broken" articles across the internet, but most of them miss the point. Email as a system is not broken, but we, through our email behavi..., METHOCARBAMOL: Central nervous system: hydrocodone: ondansetron: 2.14: 1.13–4.09: TIZANIDINE: Cardiovascular: atorvastatin: gabapentin: 1.45: 1.06–1.98: losartan: …, Your calves and ankles are under-appreciated muscles that work hard to keep your body steady and balanced while you’re standing, walking, or running. You might already be stretchin..., The primary indications for cyclobenzaprine, metaxolone, methocarbamol, and carisoprodol are acute painful musculoskeletal conditions. 16 Baclofen and tizanidine are indicated for spasticity associated with UMN disorders, but are frequently used off-label for painful musculoskeletal conditions. Diazepam is indicated for UMN muscle spasticity ..., The FDA has not approved tizanidine to treat neck or back pain. For multiple sclerosis or cerebral palsy, tizanidine tends to have fewer side effects than Baclofen. But either medication may not make much difference in new low back pain when compared with ibuprofen alone. Tizanidine is not a first choice for new neck or back muscle pain. 6 ..., Tizanidine belongs to a group of medications called muscle relaxants. Tizanidine ... muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, ..., The primary indications for cyclobenzaprine, metaxolone, methocarbamol, and carisoprodol are acute painful musculoskeletal conditions. 16 Baclofen and tizanidine are indicated for spasticity associated with UMN disorders, but are frequently used off-label for painful musculoskeletal conditions. Diazepam is indicated for UMN muscle spasticity ...